Endocrine Abstracts

Introduction: Overt thyroid dysfunction in pregnancy without an early diagnosis and treatment may lead to an increased risk of adverse maternal and fetal outcomes. In this study, our goal was to assess the results of the development of a laboratory alerting system for the diagnosis of thyroid dysfunction in the first trimester of pregnancy. Material and methods: Observational retrospective study evaluating clinical and biochemical data from pregnant wome...

Introduction: Bariatric surgery is an effective therapy for patients with type 2 diabetes mellitus (T2D). Many mechanisms have been proposed for its metabolic benefits, such as caloric restriction, weight loss, increased secretion of gut hormones like glucagon-like peptide 1 (GLP-1) and 2 (GLP-2), bile acid diversion, decrease of pancreatic and hepatic fat deposits and changes in gut microbiome.Aims: Evaluate changes after surgery in gut microbiome profi...

Introduction: DM 1 is proposed as a condition of accelerated muscle aging and mitochondrial dysfunction as a common link regulating muscle deterioration in aging and DM 1. Loss of muscle mass is associated with insulin resistance, metabolic syndrome and cardiovascular complications.Objectives: To analyze body composition and metabolic variables related to insulin resistance in overweight/obese patients with DM1.Material and MethodsObservational, cross-se...

Recently, human cerebral organoids (hCOs) emerged as powerful three-dimensional in vitro models recapitulating key aspects of early human cerebral cortex development. Improved protocols for hCO generation from induced pluripotent stem cells (hiPSC) paved the way for new disease modeling approaches and enable multimodal analyses of perturbed neurogenesis resulting from manipulation of signaling pathways or gene function. These prospects prompted us to adopt this techno...

Introduction: Metabolic dysfunction-associated fatty liver disease (MAFLD) is characterized by the presence of hepatic steatosis, which can progress to non-alcoholic steatohepatitis (NASH), fibrosis, and hepatocellular carcinoma. There are no licensed therapies to halt MAFLD progression, despite it is becoming the most important etiology for advanced liver disease.Aim: The aim of the study was to evaluate the therapeutic potential of inorganic nanopartic...

Aim: Epicardial adipose tissue (EAT) has important physiologic functions, nonetheless, excessive EAT leads to a proinflammatory state with adverse effects on the myocardium. EAT has also been associated with adverse outcomes in chronic kidney disease (CKD) patients. We think that visceral adipose tissue (VAT) and organ-specific ectopic fat plays an important role in cardiorenal dysfunction. The aim of our study is to analyse the relationship between EAT and the risk of develop...

Lung carcinoids are slow-proliferating neuroendocrine neoplasms commonly showing low mutational burden but a high heterogeneity and difficult clinical management. Despite valuable advances in their molecular characterization, some aspects remain still unknown. Recent studies have shown that alternative splicing is severely dysregulated in lung carcinoids, where it could promote tumoral features. In contrast, the role of some molecular systems closely related to splicing and ot...

Introduction: Fine-needle biopsy with cytologic evaluation remains the diagnostic test of choice to distinguish benign from malignant thyroid nodules, but fails to classify thyroid nodules in 15% to 30% of cases (indeterminate thyroid nodules-ITN). ‘Rule out’ molecular testing improves the diagnostic accuracy, with high sensitivity and negative predictive value, ranging from 86 to 96%. However, these tests are not widely available, and notably increase costs. <p ...

Introduction: Urine free cortisol measurements are routinely performed to evaluate hypercortisolism. Despite their analytical inaccuracy, immunoassay-based methods are frequently used. Advances in liquid chromatography high resolution mass spectrometry (LC-HRMS) facilitate the incorporation of powerful diagnostic tools into clinical laboratories with high analytical specificity that also allow simultaneous quantification of different metabolites and untargeted compound identif...

Introduction: Cinacalcet is a positive allosteric modulator of the calcium sensing receptor successfully used to decrease serum calcium in primary hyperparathyroidism (pHPT) patients in the short-term, but long-term data are scarce. In this single-centre retrospective analysis, we investigated the efficacy and safety of cinacalcet in pHPT patients who received more than 5 years of treatment.Methods: Statistical analysis was performed using free online so...